Linear IgA and IgG bullous dermatosis*
نویسندگان
چکیده
Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.
منابع مشابه
Three cases of linear IgA/IgG bullous dermatosis showing IgA and IgG reactivity with multiple antigens, particularly laminin-332.
IMPORTANCE Linear IgA/IgG bullous dermatosis (LAGBD) is a relatively rare autoimmune bullous disease characterized by both IgA and IgG antibodies to epidermal basement membrane zone. The heterogeneity and pathogenesis of the LAGBD autoantigens have not been fully elucidated. OBSERVATIONS We report 3 Japanese cases of LAGBD (ages 81, 88, and 64 years; 1 woman and 2 men). The patients showed bu...
متن کاملLocalized linear IgA/IgG bullous dermatosis.
Linear IgA/IgG bullous dermatosis (LAGBD) is an auto-immune blistering disease characterized by the local accumulation of IgA- and IgG-class anti-basement membrane autoantibodies. It typically presents as a generalized pruritic vesiculobullous eruption. No cases of localized LAGBD have yet been reported. We report a case of a 78-year-old man with LAGBD localized to the perianal area. The patien...
متن کاملInterstitial pneumonia associated with linear immunoglobulin A/immunoglobulin G bullous dermatosis.
A 76-year-old man with interstitial lung disease was admitted to our institution after developing persistent dyspnea upon effort. He also had a relapse of bullous eruptions on the skin of the trunk and extremities, previously diagnosed as vesicular pemphigoid. Direct immunofluorescence of a skin biopsy specimen using fluorescence microscopy showed the linear deposition of immunglobulin A (IgA),...
متن کاملLinear IgA bullous dermatosis (LABD) is characterised by linear deposition of IgA along basement membrane
© 2015 The Authors. doi: 10.2340/00015555-1923 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Linear IgA bullous dermatosis (LABD) is characterised by linear deposition of IgA along basement membrane zone (BMZ) in direct immunofluorescence (IF) (1). The term of linear IgA/IgG bullous dermatosis (LAGBD) was proposed for some cases, which showed IgA and IgG deposition to BM...
متن کاملA case of linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies.
Fig. S1. Immunoblot analysis using purified human laminin-332. Lane 1 is for IgG autoantibodies of anti-laminin-332 MMP control, lane 2 for IgG autoantibodies of normal control, lane 3 for patient IgG autoantibodies, and lane 4 for patient IgA autoantibodies. Both IgG and IgA from the patient reacted with the 165-kDa and 145-kDa forms of α3 subunit, as well as the 105-kDa γ2 subunit of laminin-...
متن کاملA morbilliform variant of vancomycin-induced linear IgA bullous dermatosis.
BACKGROUND Linear IgA bullous dermatosis is an autoimmune blistering disease characterized clinically by the presence of small tense blisters and immunologically by the presence of IgA at the dermal-epidermal junction. Idiopathic, systemic disease-related, and drug-related versions of this disorder have been described, with the latter most commonly associated with vancomycin. OBSERVATIONS We ...
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عنوان ژورنال:
دوره 91 شماره
صفحات -
تاریخ انتشار 2016